Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity
نویسندگان
چکیده
منابع مشابه
lncRNA-RNA Interactions across the Human Transcriptome
Long non-coding RNAs (lncRNAs) represent a numerous class of non-protein coding transcripts longer than 200 nucleotides. There is possibility that a fraction of lncRNAs are not functional and represent mere transcriptional noise but a growing body of evidence shows they are engaged in a plethora of molecular functions and contribute considerably to the observed diversification of eukaryotic tra...
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Long noncoding RNAs (lncRNAs) play a key role in the epigenetic regulation of cells. Many of these lncRNAs function by interacting with histone repressive proteins of the Polycomb group (PcG) family, recruiting them to gene loci to facilitate silencing. Although there are now many RNAs known to interact with the PRC2 complex, little is known about the details of the molecular interactions. Here...
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Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of chromatin domains repressive to transcription through catalysis of methylation of histone H3 at Lys27 (H3K27me2/3). However, through its EZH2 subunit, PRC2 also binds to nascent transcripts from active genes that are devoid of H3K27me2/3 in embryonic stem cells. Here, biochemical analyses indicated that RNA inte...
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Emerging evidence implicates that a large fraction of human genome was transcribed but the transcripts known as long non coding RNA are not translated into proteins. They are contributing in different cellular processes, including cellular proliferation and apoptosis. LncRNAs were found to play critical roles in many diseases and act as key regulators in malignancies. In this study, we investig...
متن کاملبیان LncRNA HOX transcript antisense RNA در بیماران تازه تشخیص داده شده لوسمی لنفوبلاستیک حاد
چکیده سابقه و هدف لوسمی حاد لنفوبلاستی، شایع‌ترین بدخیمی دوران کودکی می‌باشد. سالانه در کل دنیا به ازای هر 100 هزار نفر،1 تا 7/4 نفر به این بیماری مبتلا می‌شوند. Long non-coding RNA ها (lncRNAs)، گروهی از RNAهای غیرکدشونده هستند که در فرآیندهای زیستی از جمله تغییرات اپی‌ژنتیکی، کنترل رونویسی و ترجمه نقش دارند. استفاده از lncRNA های اختصاصی خونی و شناسایی عملکرد آن‌ها می‌تواند در شناخت بیشتر پا...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2021
ISSN: 2375-2548
DOI: 10.1126/sciadv.abc9191